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目的探讨利拉鲁肽联合二甲双胍治疗2型糖尿病的效果。方法回顾分析2011年6月至2012年6月期间在我科住院治疗的2型糖尿病患者80例的临床资料。在继续服用入院前药物(二甲双胍)的前提下,加用利拉鲁肽注射液1次/d晨起皮下注射,疗程8周。治疗后观察疗效。结果患者体重减轻,2 hPBG、FBG、HbA1 c、C肽等明显下降,不良反应症状均较轻,能耐受,在1周之内症状缓解,发生低血糖3例,症状轻,适当降低用药剂量,未产生严重后果。结论利拉鲁肽联合二甲双胍治疗2型糖尿病作用显著,能减轻体重,不良反应少,低血糖风险小,值得广大学者做进一步的研究。
Objective To investigate the effect of liraglutide combined with metformin on type 2 diabetes mellitus. Methods The clinical data of 80 patients with type 2 diabetes hospitalized in our department from June 2011 to June 2012 were retrospectively analyzed. Before continuing to take pre-hospital drug (metformin) under the premise, plus liraglutide injection 1 / d morning subcutaneous injection, the course of 8 weeks. After treatment, observe the effect. Results The body weight of patients was significantly lower than that of 2 hPBG, FBG, HbA1 c and C-peptide. The adverse reaction symptoms were mild and able to tolerate. Within 1 week, the symptoms were relieved. Hypoglycemia occurred in 3 cases and the symptoms were mild. Dose, did not produce serious consequences. Conclusion The combination of liraglutide and metformin has significant effects on type 2 diabetes mellitus, which can reduce body weight, fewer side effects and low risk of hypoglycemia. It deserves further study.