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用小鼠子宫颈癌14号(U14)细胞脾内移植的方法,建立肝转移形成的模型。结果表明以1x10~6或更多的癌细胞脾内移植,肝转移发生率较高.在癌细胞移植后不同时间切除脾脏(切除原发瘤),证明癌细胞并非由于机械压力而是自发转移到肝内。这一实验模型对肿瘤肝转移的机制和防治等研究将提供有用的实验工具.
A model of hepatic metastasis was established by intrasplenic transplantation of mouse cervical cancer No. 14 (U14) cells. The results showed that the incidence of hepatic metastasis was higher in spleen transplantation with 1x10~6 or more cancer cells. The spleen was removed at different times after the cancer cells were transplanted (resection of primary tumors), which proved that the cancer cells were not due to mechanical pressure but spontaneous metastasis. Into the liver. This experimental model will provide useful experimental tools for the study of the mechanism and prevention of liver metastases.