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目的:探讨从两性霉素B治疗侵袭性肺曲霉病寻找临床切入点的途径。方法:对慢性阻塞性肺疾病合并侵袭性肺曲霉菌病患者使用两性霉素B治疗过程中发生肾损害案例进行分析,提出适时药学监护。结果:及时根据肾功能指标调节药物剂量和处理两性霉素B相关不良反应,患者好转出院。结论:两性霉素B不良反应多,治疗过程中应加强药学监护,临床药师应从细节方面协助临床医师,保障安全、有效、合理用药。
Objective: To explore ways to find clinical entry points from amphotericin B in the treatment of invasive pulmonary aspergillosis. Methods: The patients with chronic obstructive pulmonary disease combined with invasive pulmonary aspergillosis were treated with amphotericin B during the treatment of renal damage cases were analyzed, put forward timely medical care. Results: Timely adjusted dose of renal function indicators and amphotericin B-related adverse reactions, the patient was discharged. CONCLUSION: Amphotericin B has many side effects and should be taken care of during the course of treatment. Clinical pharmacists should assist clinicians in details to ensure safe, effective and reasonable medication.