目的研究单用胸腺肽α_1(thymosin alpha-1,Tα_1,zadaxin)对慢性乙型肝炎(CHB)的治疗作用。方法通过MEDLINE、PUBMED、Blackwell等电子数据库搜寻有关Tα_1治疗慢性乙型肝炎的相关资料,加以统计学上的比较、分析、观察及评价其对CHB的治疗效果。结果对7个研究胸腺肽α_1(zadaxin)单用治疗慢性乙型肝炎的随机对照实验进行临床荟萃分析发现,Tα_1单用的疗效(38%)几乎是对照组(13%)的3倍,在统计学上差异有显著性意义。结论胸腺肽α_1单用治疗CHB能取得较好的临床治疗效果,与干扰素相比不仅表现在能有效地减少乙肝病毒(HBV)复制,较少不良反应,为机体较好地耐受,而且诱导了持续的、递增的血清丙氨酸转氨酶(ALT)复常和HBV-DNA的清除。 Objective To investigate the therapeutic effect of thymosin α-1 (Tα_1, zadaxin) on chronic hepatitis B (CHB). Methods The electronic databases of MEDLINE, PUBMED and Blackwell were used to search the related data of Tα_1 in the treatment of chronic hepatitis B, and the data of CHB were statistically analyzed, compared, analyzed and evaluated. Results A meta-analysis of 7 randomized controlled trials of thymosin alpha 1 (zadaxin) alone in the treatment of chronic hepatitis B found that the efficacy of Tα 1 alone (38%) was almost 3-fold that of the control group (13%), Differences in learning have significant significance. Conclusions Thymosin alpha 1 alone can improve the clinical curative effect of CHB. Compared with interferon, the therapeutic effect of thymosin alpha 1 can not only reduce HBV replication but also have fewer adverse reactions, which are better tolerated by the body and induced A sustained, increasing serum alanine aminotransferase (ALT) remnant and HBV-DNA clearance.