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目的了解医院药品不良反应(ADR)发生的情况及特点,为临床合理用药及药物安全性评价提供参考。方法对2008~2010年收集的630例不良反应报告表,分别从患者年龄、给药途径、药品种类、抗微生物药物类别、累及的器官或系统及临床表现等方面进行统计分析。结果 ADR多发生在大于60岁年龄组(23.81%);静脉滴注导致的ADR发生率最高,占71.59%;ADR发生率最高的为抗微生物药物,为62.54%,其中头孢菌素类药物最多,占118例;ADR的临床表现以皮肤及其附件损害最为常见,占44.76%。结论引起ADR的因素有多方面,应加强ADR监测,促进临床合理用药,减少ADR的发生。
Objective To understand the occurrence and characteristics of Adverse Drug Reactions (ADR) in hospitals and provide references for clinical rational drug use and drug safety evaluation. Methods A total of 630 ADRs collected from 2008 to 2010 were analyzed statistically in terms of patient age, route of administration, type of drug, antimicrobial drug category, organ or systemic and clinical manifestations involved. Results The incidence of ADR occurred in more than 60 years old group (23.81%). The incidence of ADR caused by intravenous infusion was the highest (71.59%). The highest incidence of ADR was antimicrobial drug (62.54%), of which cephalosporins , Accounting for 118 cases. The clinical manifestations of ADR were the most common lesions (44.76%). Conclusion There are many factors that cause ADR. We should strengthen the monitoring of ADR, promote the rational use of drugs and reduce the occurrence of ADR.