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目的:探讨复发性外阴阴道念珠菌病(RVVC)的有效治疗方法。方法:2008～2010年随机选择72例RVVC育龄期妇女进行阴道上药联合醋水坐浴治疗。A组36例,治疗时间为月经前1天、前2天+月经干净后1天,后2天+排卵期前1天,前2天+排卵期后1天、后2天。B组36例,治疗时间为月经前3天、前4天+月经干净后3天,后4天+排卵期前3天,前4天+排卵期后3天、后4天。阴道上药:克霉唑栓每晨0.1 g,制霉菌素栓每晚40万单位;醋水坐浴:食用醋+温开水,pH值4.8～5.0,20 min/次,2次/d;重复治疗2月为1个疗程。停药后7～14天及3月、6月分别评价近期治愈率及远期复发率。结果:A组和B组RVVC近期治愈率及远期复发率分别为100.0%和5.6%、69.4%和28.0%(P<0.05)。结论:围经期及围排卵期阴道上药联合醋水坐浴是治疗RVVC的有效方法。
Objective: To investigate the effective treatment of recurrent vulvovaginal candidiasis (RVVC). Methods: From 2008 to 2010, 72 women with RVVC at childbearing age were randomly selected for vaginal drug treatment combined with vinegar water bath treatment. A group of 36 patients, treatment time is 1 day before menstruation, 2 days before menstruation clean 1 day, 2 days after ovulation + 1 day, 2 days before ovulation + 1 day and 2 days after ovulation. Group B, 36 cases, treatment time is 3 days before menstruation, the first 4 days + menstrual clean 3 days after 4 days + 3 days before ovulation, the first 4 days + 3 days after ovulation, 4 days after. Vaginal drugs: clotrimazole suppository 0.1 g per morning, nystatin suppository 400,000 units per night; vinegar water bath: vinegar + warm water, pH 4.8 ~ 5.0,20 min / times, 2 times / d; Repeat treatment in February for a course of treatment. After the withdrawal of 7 to 14 days and March, June, respectively, evaluation of the recent cure rate and long-term recurrence rate. Results: The recent cure rates and long-term recurrence rates of RVVC in groups A and B were 100.0% and 5.6%, 69.4% and 28.0%, respectively (P <0.05). Conclusion: Vaginal vaginal administration and vinegar water bathing in perimenopausal period and ovulation period are effective methods for the treatment of RVVC.