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成年雄性新西兰兔分别用普通饲料、高胆固醇饲料、高胆固醇与Ｌ－精氨酸混合饲料饲养１０周，结果高胆固醇组血中ＭＤＡ、动脉条中丙二醛／蛋白ＭＤＡ／ｐｒｏ、ＴｘＢ２的含量明显高于普通饲料组（Ｐ＜０．０１），血中ｃＧＭＰ的含量明显低于普通饲料组（Ｐ＜０．０１），而混合饲料组上述指标与普通饲料组无明显差异，与高胆固醇组却有显著差异，表明外源性胆固醇可导致血中、动脉条中的自由基、ＴｘＢ２水平明显增高，ＮＯ水平明显减低。补充外源性Ｌ－精氨酸可调节内源性ＮＯ的产生，对自由基、ＴｘＢ２等有明显的拮抗作用。
Adult male New Zealand white rabbits were fed with normal diet, high cholesterol diet, high cholesterol and L-arginine mixed diet for 10 weeks, the results of hypercholesterolemia blood MDA, arterial strips of malondialdehyde / protein MDA / pro, TxB2 content (P <0.01), and the content of cGMP in blood was significantly lower than that of the normal feed group (P <0.01), while the above indicators of the mixed feed group had no significant difference with the normal feed group, There was a significant difference between the groups, indicating that exogenous cholesterol can lead to blood, arterial strips of free radicals, TxB2 levels were significantly higher, NO levels were significantly lower. L-arginine supplementation can regulate the production of endogenous NO, free radical, TxB2 and other obvious antagonism.