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2型糖尿病(T2DM)患者的家族成员发生糖尿病(DM)和糖耐量减低(IGT)的机会远高于非糖尿病患者的家族成员,其中一级亲属更是糖尿病家系中的高危人群[1]。本研究探讨2型糖尿病患者正常糖耐量一级亲属胰岛素抵抗(IR)和B细胞功能,以及脂联素水平在2型糖尿病发病中的作用。1对象与方法
Families with type 2 diabetes (T2DM) have far more chances of developing diabetes mellitus (DM) and impaired glucose tolerance (IGT) than their nondiabetic counterparts, with first-degree relatives more likely to be at high risk of developing diabetes mellitus. [1] This study investigated the role of insulin resistance (IR) and B cell function in normal glucose tolerance first-degree relatives of type 2 diabetic patients and the role of adiponectin in the pathogenesis of type 2 diabetes. 1 objects and methods