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苯甲酸钠分子式为C_7H_5O_2Na,其滴定产物苯甲酸的Ka=6.4×10~(-5)(25℃)酸性较强,故苯甲酸钠一般不能用酸直接滴定。中国药典(1977年版)、英国药典(1980年版)及日本药局方第十改正版皆采用双相滴定法进行含量测定。该法需用大量的乙醚进行萃取,操作繁琐,乙醚易燃、有毒、危险。美国药典(XXI)用非水滴定法铡定其含量,亦受一定条件限制。本文鉴于D.Stefanovic首先把交流示波极谱滴定用于中和反应,陈
Sodium benzoate molecular formula C_7H_5O_2Na, the titration product of benzoic acid Ka = 6.4 × 10 -5 (25 ° C) is more acidic, so the general sodium benzoate can not be directly titrated with acid. Chinese Pharmacopoeia (1977 edition), the British Pharmacopoeia (1980 edition) and the Japanese Pharmacopoeia tenth revised edition are used two-phase titration method for determination. The law requires a large number of ether extraction, cumbersome operation, ether flammable, toxic and dangerous. The United States Pharmacopeia (XXI) non-aqueous titration 铡 set its content, but also subject to certain conditions. In this article, D.Stefanovic first used AC oscillometric titration for the neutralization reaction, Chen