免疫学家在研究TCRαβ介导免疫识别的发育及结构的同时发现了一类新的T细胞亚群,它既不同于CD_8~+溶细胞性TCRαβ细胞,又不同于CD_4~+辅助性TCRαβ细胞,它由二硫键联结γ-和δ-基因产物(γ、δ键)组成。笔者近几年来着重研究TCRαβ细胞的胚系发生、多样性及其分子结构。众所周知,TCRγ基因是Tonegawa 等在寻求TCRαβ二聚体中α基因重排时发现的,γ基因虽可从TCRαβ细胞中分离到,但其编码的蛋白质并不参与TCRαβ细胞的功 Immunologists in the study of TCRαβ-mediated immune recognition of the development and structure of a new class of T cells found at the same time, it is different from the CD_8 ~ + cytolytic TCRαβ cells, but also different from CD_4 ~ + TCRαβ supporting cells , Which consists of disulfide linked γ- and δ-gene products (γ, δ bonds). In recent years, the author focuses on the germline occurrence, diversity and molecular structure of TCRαβ cells. It is well-known that the TCRγ gene was discovered by Tonegawa et al in the search for α gene rearrangements in TCRαβ dimer. Although the γ gene can be isolated from TCRαβ cells, the protein it encodes does not participate in the function of TCRαβ cells