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应用免疫组织化学ABC法、S-P法对67例乳腺肿瘤进行了EGF、EGF-R、p53癌基因蛋白表达的研究。结果显示:EGF表达阳性率为17.9%,髓样癌阳性率最高(27.2%)。EGF-R表达阳性率为67.16%,单纯癌阳性率最高(68.75%)。p53表达阳性率为37.31%,单纯癌阳性率最高(50%)。EGF、EGF-R、p53之间阳性表达有明显相关性,P<0.01,与淋巴结转移相关。两者同时过度表达和三者同时过度表达者也与淋巴结转移有关,与预后无明显差异。提示EGF、EGF-R、p53在乳腺肿瘤浸润、增殖及淋巴结转移中起重要作用。
The expression of EGF, EGF-R, and p53 oncogene proteins in 67 cases of breast tumors were studied by immunohistochemical ABC method and S-P method. The results showed that the positive rate of EGF expression was 17.9%, and the positive rate of medullary carcinoma was the highest (27.2%). The positive rate of EGF-R expression was 67.16%, and the highest positive rate was 68.75%. The positive rate of p53 expression was 37.31%. The positive rate of p53 was highest (50%). The positive expression of EGF, EGF-R, and p53 was significantly correlated, P<0.01, and correlated with lymph node metastasis. Both overexpression and overexpression of the three were also associated with lymph node metastasis, with no significant difference in prognosis. It suggests that EGF, EGF-R, p53 play an important role in breast tumor invasion, proliferation and lymph node metastasis.