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目的对中国人纤维蛋白原β链基因-148C/T、-455G/A多态性与脑梗死相关性的研究进行Meta分析。方法通过文献检索收集自1994年1月1日至2005年12月30日发表的中国人纤维蛋白原β链基因-148C/T、-455G/A多态性与脑梗死关系的病例-对照研究,剔除不符合要求的文献,以漏斗图检验入选文献的发表偏倚,并根据各入。选文献结果的同质性检验结果进行数据合并,计算总OR值,Meta分析采用Review Manager 4.2版统计软件。结果共9篇关于-148C/T多态性和11篇关于-455G/A多态性的文献符合条件纳入研究,入选文献无明显发表偏倚,各文献同质性检验显示有关-148C/T(x~2=16.42,P=0.04)和-455G/A(x~2=29.89,P=0.0009)多态性文献间均存在显著异质性。数据合并结果显示-148C/T多态性位点(C/T+T/T)比C/C发生脑梗死的OR值为1.35,95%CI为1.02～1.78(P=0.03),-455G/A多态性位点(G/A+A/A)比G/G发生脑梗死的OR值为1.38,95%CI为1.03～1.85(P=0.03)。结论纤维蛋白原β链基因-148C/T、-455G/A多态性与中国人脑梗死易感性相关,-148T、-455A等位基因可能是脑梗死的遗传危险因素。
Objective To analyze the association between -148C / T and -455G / A polymorphisms of β-chain gene of fibrinogen and cerebral infarction in Chinese. Methods A case-control study on the relationship between the -148C / T and -455G / A polymorphisms of fibrinogen β-chain gene and cerebral infarction in Chinese from January 1, 1994 to December 30, 2005 was collected through literature search , Remove the unqualified literature, funnel plot to verify the publication of the selected publication bias, and according to each entry. The results of homogeneity of selected literature results were combined data, calculate the total OR, Meta analysis using Review Manager 4.2 statistical software. Results A total of 9 articles on the -148C / T polymorphism and 11 articles on the -455G / A polymorphism were included in the study. There was no obvious publication bias in the selected articles. The homogeneity tests of all the literature showed that -148C / T There was significant heterogeneity among the polymorphisms of -455G / A (x ~ 2 = 29.42, P = 0.0009) and -455G / A The pooled data showed that the OR of the -148C / T polymorphism (C / T + T / T) vs C / C was 1.35 and 95% CI was 1.02-1.78 (P = 0.03) / A polymorphism (G / A + A / A) ratio of G / G in cerebral infarction was 1.38,95% CI 1.03 to 1.85 (P = 0.03). Conclusion The -148C / T and -455G / A polymorphisms of fibrinogen β chain gene are associated with the susceptibility to cerebral infarction in China. The -148T and -455A alleles may be the genetic risk factors for cerebral infarction.