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众所周知,使用抗菌药经常引起正常肠道微生物群落的生态学平衡的混乱。抗菌药可能对许多正常肠道微生物群落有潜在的副作用。不同因素影响特定抗菌药作用正常微生物群落的程度,最主要的因素是口服药物的不完全吸收。吸收不好的药物以活性形式能达到肠道,而破坏易受影响的微生物并改变生态学平衡。现就各种不同喹诺酮药物对人的肠道微生物群落的影响介绍如下。 1、环丙沙星(Ciprofloxacin) 喹诺酮类药物中研究最多的是环丙沙星。12例志愿者给药500mg每日2次共7天,肠杆菌被消除,链球菌明显减少,未观察到对厌氧菌菌落的影响,停药1周后,群落恢复到正常。6例用药500mg每日1次共7天,肠杆菌被抑制,2例对环丙沙星耐
It is well known that the use of antibacterials often causes confusion in the ecological balance of the normal intestinal microflora. Antibacterials may have potential side effects on many normal intestinal microflora. The most important factor that affects the extent to which different antibacterials affect normal microbial communities is the incomplete absorption of oral medications. Poorly absorbed drugs reach the intestine in active form, destroying the susceptible microorganisms and changing the ecological balance. The effects of different quinolone drugs on human intestinal microflora are presented below. 1, Ciprofloxacin Quinolones most studied is ciprofloxacin. Twelve volunteers administered 500 mg twice daily for 7 days. Enterobacteria were eliminated and streptococci were significantly reduced. No effect on anaerobic colonies was observed. After one week of withdrawal, the community returned to normal. 6 cases treated with 500mg once daily for 7 days, enterobacteriaceae were inhibited, and 2 were resistant to ciprofloxacin