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作者用同位素~(125)碘标记猪胸腺素并观察其在小白鼠、兔体内的分布与代谢。动物肌肉注射胸腺素很快进入血液中,小鼠在1小时即达最高值,以后逐步降低,12小时的浓度为最高含量的50%,第3日残留量小于5%。家兔的代谢较小鼠慢,血液中浓度的最高值出现在1～2小时左右,但降至最高值的50%需3天,降至5%以下约需14天。检查粪尿中放射性排出量,小鼠需1天即排出总放射量的52%,至14天由粪尿排出约70%。检查各脏器,一般第1小时放射性强度最高,72小时除肝脏外已全排出,肾脏在第2小时放射性强度最高,72小时仍有相当量残留。
The author used isotope 125 iodine labeled pig thymosin and observed in mice, rabbit body distribution and metabolism. Intramuscular injection of thymosin quickly into the blood, the mice reached the highest value in 1 hour, and then gradually reduced, 12-hour concentration of 50% of the maximum content, the 3rd residue was less than 5%. The metabolism of rabbits is slower than that of the mice. The highest concentration of blood appears in about 1 to 2 hours, but it takes 3 days to decrease to 50% of the maximum value and 14 days to below 5%. Examination of excretion of radioactive excretion of urine, mice need to discharge 52% of the total emissions of 1 day, 14 days by the excretion of about 70%. Check the organs, usually the first hour of the highest intensity of radioactivity, except for the liver has been discharged in 72 hours, the highest in the first 2 hours of radioactivity in the kidneys, 72 hours still a considerable amount of residue.