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1例68岁男性患者因多发性脑梗死、原发性高血压及糖尿病口服阿司匹林0.1 g1,次/d;氯吡格雷75 mg,1次/d;氨氯地平5 mg,1次/d;瑞舒伐他汀10 mg,每晚1次;静脉滴注依达拉奉30 mg2,次/d;银杏叶提取物20 ml1,次/d;奥拉西坦4 g,1次/d。6 d后行脑血管造影及右侧颈内动脉窦部支架植入术。术后当晚患者突发左侧肢体无力。随后逐渐出现胸口针刺样疼痛、尿量减少。肌酸激酶及肌红蛋白最高值分别为2754 U/L和10 999μg/L,诊断为瑞舒伐他汀所致横纹肌溶解症。停用瑞舒伐他汀,其他药物继续应用,同时行持续性肾脏替代治疗、抗感染治疗及补液等对症治疗后,患者病情逐渐好转。
A 68-year-old male patient was given aspirin 0.1 g 1, times / d due to multiple cerebral infarction, essential hypertension and diabetes mellitus; clopidogrel 75 mg once daily; amlodipine 5 mg once daily; Rosuvastatin 10 mg once night, intravenous edaravone 30 mg2, times / d; ginkgo biloba extract 20 ml1, times / d; oxiracetam 4 g, 1 time / d. 6 days after cerebral angiography and right internal carotid sinus stent implantation. Patients with sudden left limb weakness after surgery. Then gradually acupuncture chest pain, decreased urine output. The highest values of creatine kinase and myoglobin were 2754 U / L and 10 999 μg / L respectively, which were diagnosed as rosuvastatin-induced rhabdomyolysis. Stop using rosuvastatin, other drugs continue to be used, while undergoing continuous renal replacement therapy, anti-infective therapy and rehydration and other symptomatic treatment, the patient’s condition gradually improved.