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AIM:To investigate the survival rates and prognostic factors in patients with hepatitis B virus-related acuteon-chronic liver failure(HBV-ACLF).METHODS:Clinical data in hospitalized patients with HBV-ACLF admitted from 2006 to 2009 were retrospectively analyzed.Their general conditions and survival were analyzed by survival analysis and Cox regression analysis.RESULTS:A total of 190 patients were included in this study.The overall 1-year survival rate was 57.6%.Patients not treated with antiviral drugs had a significantly higher mortality[relative risk(RR)=0.609,P=0.014].The highest risk of death in patients with ACLF was associated with hepatorenal syndrome(HRS)(RR=2.084,P=0.026),while other significant factors were electrolyte disturbances(RR=2.062,P=0.010),and hepatic encephalopathy(HE)(RR=1.879,P<0.001).CONCLUSION:Antiviral therapy has a strong effect on the prognosis of the patients with HBV-ACLF by improving their 1-year survival rate.HRS,electrolyte disturbances,and HE also affect patient survival.
AIM: To investigate the survival rates and prognostic factors in patients with hepatitis B virus-related acuteon-chronic liver failure. METHODS: Clinical data in hospitalized patients with HBV-ACLF admitted from 2006 to 2009 were retrospectively analyzed. total conditions and survival were analyzed by survival analysis and Cox regression analysis. RESULTS: A total of 190 patients were included in this study. Overall 1-year survival rate was 57.6%. Patients not treated with antiviral drugs had a significantly higher mortality [ relative risk (RR) = 0.609, P = 0.014] .The highest risk of death in patients with ACLF was associated with hepatorenal syndrome (HRS) (RR = 2.084, P = 0.026), while other significant factors were electrolyte disturbances (RR = 2.062, P = 0.010), and hepatic encephalopathy (HE) (RR = 1.879, P <0.001) .CONCLUSION: Antiviral therapy has a strong effect on the prognosis of the patients with HBV- ACLF by improving their 1-year survival rate. HRS, electrolyte disturbances, and HE also affe ct patient survival.