肾上腺皮质癌所致皮质醇增多症(柯兴氏综合征)较少见,本组7例均有典型的皮质醇增多症的主要临床症状与体征,其中4例女性皆有不同程度的男性化表现。7例腹部均扪及包块,其中3例有明显肝肿大及肝功能异常。实验室检查除尿17OH,17KS 明显增高外,DHEA 对诊断有一定帮助。本病恶性度高,进展迅速,病理报告为大腺瘤者有潜在癌变的可能性,应密切观察及随访。 Adrenocortical carcinoma caused by cortisol hyperplasia (Cushing’s syndrome) is rare, the 7 cases of this group all have the typical clinical symptoms and signs of hypercortisolism, of which 4 women have varying degrees of masculinization. which performed. Abdominal sacral masses and masses were found in 7 cases, of which 3 cases had obvious hepatomegaly and abnormal liver function. In addition to urine 17OH, 17KS increased significantly in laboratory tests, DHEA is helpful for diagnosis. The disease is highly malignant and progresses rapidly. The pathology report is likely to be potentially cancerous in macroadenomas and should be closely observed and followed up.