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探讨免疫功能在矽肺发病中的作用。用流式细胞仪检测36名矽肺患者(矽肺组)和36名健康人(健康组)外周血CD3、CD4、CD8、NK细胞及CD4/CD8比值。结果显示,矽肺组的CD3、CD4、NK细胞百分数较健康组明显下降(P<0.01或P<0.05),CD4/CD8比值较健康组明显下降(P<0.05或P<0.01),CD8百分数较健康组明显上升(P<0.05)。提示,矽肺患者免疫功能紊乱在疾病发生发展中起到重要作用。
To explore the role of immune function in silicosis. Flow cytometry was used to detect the ratio of CD3, CD4, CD8, NK cells and CD4 / CD8 in 36 patients with silicosis (silicotic group) and 36 healthy people (healthy group). The results showed that the percentage of CD3, CD4 and NK cells in silicosis group was significantly lower than that in healthy group (P <0.01 or P <0.05), and the ratio of CD4 / CD8 in silicosis group was significantly lower than that in healthy group (P <0.05 or P <0.01) The health group increased significantly (P <0.05). Prompted that the immune function of silicosis patients play an important role in the development of the disease.