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[目的]研究白藜芦醇对兔膝骨性关节炎模型的保护作用.[方法]将40只成年新西兰兔(限雄性)作为实验兔,随机分为5组,正常组、模型组、低剂量白藜芦醇组、中剂量白藜芦醇组、高剂量白藜芦醇组,模型组及白藜芦醇组采用Hulth经典方法造骨关节炎模型.术后4周造模成功,各组分别干预,10周后行X线片检测,并取膝关节标本行HE染色、Mankins评分、microCT扫描,数据作统计学处理.[结果]与模型组相比,白藜芦醇处理组的X线膝关节间隙改变和镜下软骨退变明显减轻.此外,白藜芦醇组的组织学Manking评分和microCT的软骨下骨骨量体积比(BV/TV)及骨小梁数目(Tb.N)值也以剂量依赖的方式减低,各组间差异有统计学意义(P＜0.05).[结论]白藜芦醇能防止关节软骨退变,从而延缓骨关节炎进程.“,”[Objective] To investigate the protective effect of resveratrol on knee osteoarthritis (OA) in a rabbit model.[Methods] Forty New Zealand rabbits (male) were randomly divided into 5 groups including normal control (group A),model control (group B),resveratrol intervention in low dosage (group C),resveratrol intervention in middle dosage (group D),as well as resveratrol intervention in high dosage (group E).The OA was surgically induced using Hulth technique in groups B,C,D,and E.As soon as the OA models were confirmed to be successful at 4 weeks after surgery,a corresponding intervention was respectively given in each group.At 10 week after surgery,the intervention effect was evaluated using X-ray examination,histological observation and micro CT scanning.[Results] Compared with the model control groups,changes of the knee joint space in X-ray film,cartilage degeneration in histological observation was remarkably diminished in the resveratrol treated groups.Additionally,the Mankins score in histological evaluation,BV/TV and Tb.N values by micro CT measurements were significantly decreased in the resveratrol treated groups in a dosage-dependent manner,associated with statistical differences among the groups (P＜0.05).[Conclusion] Resveratrol can prevent degeneration of articular cartilage,thereby delay the progression of osteoarthritis.