本文观察了某鞋厂纯甲苯作业者外周血象和淋巴细胞微核率，并测定了作业者尿中马尿酸和尿酚含量。结果：作业工人血红蛋白含量、白细胞数、血小板数明显低于对照组（Ｐ＜００５或Ｐ＜００１）；毒粒细胞数和淋巴细胞微核率明显高于对照组（均Ｐ＜００１）；接触者下班前尿酚含量高于上班前（单侧Ｐ＜００５），明显高于对照组（Ｐ＜００１），且尿酚与马尿酸含量间呈正相关关系（ｒ＝０６０４９，Ｐ＜０００５），表明尿酚与甲苯浓度可能相关，提示甲苯进入人体后，可产生血液和遗传毒性，此作用可能是甲苯在体内代谢所产生的酚类化合物所致 This article observed the pure toluene workers in a shoe factory peripheral blood lymphocytes and lymphocyte micronucleus rate, and determination of the operator of urinary hippuric acid and urinary phenol content. Results: The hemoglobin content, white blood cell count and platelet count of workers were significantly lower than those of the control group (P <005 or P <001); the number of poisoning neutrophils and lymphocyte micronucleus rate were significantly higher than those of the control group (P < 001). The level of urinary phenol before work was higher than that before work (unilateral P <005), significantly higher than that of the control group (P0.01), and there was a positive correlation between urinary phenol and hippuric acid (R = 06049, P <0005), indicating that the concentration of urine phenol and toluene may be related, suggesting that toluene into the human body, can produce blood and genotoxicity, the role of toluene in vivo metabolism may be produced by the phenolic compounds Due