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TGF-β受体所介导的信号在肿瘤发生的后期具有促进肿瘤发展的作用,这一作用被视为掌控乳腺癌细胞转移的主要调节因素.哺乳动物细胞中存在6种不同类型的肿瘤坏死因子受体(TNFR)相关因子(TRAF1~TRAF6),其中TRAF4的功能在过去的研究中并未被广泛证实.尽管大量研究已表明,TRAF4在肿瘤发生时高度表达,但其涉及的致癌机制仍未知.本文旨在阐述TRAF4参与调控TGF-β诱导发生的下游SMAD依赖型和SMAD非依赖型的2条TGF-β信号通路在乳腺癌肿瘤转移过程中的作用.
Signals mediated by the TGF-β receptor have a role in promoting tumor development late in the tumorigenesis as a major regulator of breast cancer cell metastasis.6 There are 6 different types of tumor necrosis in mammalian cells TRAF1 ~ TRAF6, the function of TRAF4 has not been widely confirmed in the past studies.Although a large number of studies have shown that TRAF4 is highly expressed in tumorigenesis, its mechanism of carcinogenesis is still involved Unknown.This paper aims to describe the role of TRAF4 in the regulation of TGF-β-induced downstream SMAD-dependent and SMAD-independent two TGF-βsignaling in breast cancer tumor metastasis.