关于三尖杉酯碱(Harringtonine)的半合成,我们已于前文作了简要的叙述,迄今为止尚未见到有关此化合物半合成成功的报道.本合成品在体内外抗肿瘤实验中均表现有生物活性.在原有工作的基础上,为了提高反应收率和进一步改进方法,对合成路线进行了深入考察.现采用的合成路线如下: For the semi-synthesis of Harringtonine, we have briefly described the above, so far there is no report on the success of this compound semisynthetic synthesis of the synthetic anti-tumor in vivo experiments have shown that there Biological activity.On the basis of the original work, in order to improve the yield of reaction and further improve the method, the synthesis route has been investigated in depth.The synthetic route is as follows: