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目的探讨本地区妇女不良妊娠结局与弓形虫IgM抗体(TOXO-IgM)的关系。方法采用酶联免疫吸附试验(ELISA)检测宁波地区89例自然流产、畸形、死胎等不良妊娠结局孕产妇及102例正常妊娠结局孕产妇外周血TOXO-IgM,并对两组间TOXO-IgM阳性率差异进行分析。结果不良妊娠结局孕产妇组TOXO-IgM阳性率显著高于正常妊娠结局孕产妇组TOXO-IgM阳性率(P(0.05),其中自然流产组及畸形孕产妇组TOXO-IgM阳性率与正常妊娠结局孕产妇组比较有非常显著差异(P(0.01)。结论提示自然流产、畸形、死胎等不良妊娠结局与弓形虫感染有密切相关,建议把TOXO-IgM检测作为育龄妇女孕前常规检查项目。
Objective To investigate the relationship between unfavorable pregnancy outcomes and TOXO-IgM in women in this area. Methods 89 cases of spontaneous abortion, malformation, stillbirth and other adverse pregnancy outcome in pregnant women and 102 cases of normal pregnancy outcome in peripheral blood of TOXO-IgM were detected by enzyme-linked immunosorbent assay (ELISA) in Ningbo. The TOXO-IgM positive Rate differences were analyzed. Results The positive rate of TOXO-IgM in pregnant women with adverse pregnancy outcomes was significantly higher than that of normal pregnant women with TOXO-IgM (P (0.05)). The positive rate of TOXO-IgM in spontaneous abortion group and normal pregnant women was positively correlated with normal pregnancy outcome (P (0.01)) .Conclusions It is suggested that adverse pregnancy outcomes such as spontaneous abortion, deformity and stillbirth are closely related to Toxoplasma gondii infection.It is suggested to use TOXO-IgM as routine examination before pregnancy for women of childbearing age.