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氟哌啶醇和卡马西平合用对心脏的毒性作用氟哌啶醇和卡马西平可用于精神病障碍，如精神分裂症的治疗。由于卡马西平对参与氟哌啶醇和三环抗抑郁剂（ＴＣＡ）代谢的细胞色素Ｐ４５０有抑制作用，故卡马西平和ＴＣＡ联用可致心脏病变（如传导延迟和心律失常），而由Ｐ４５０...
Halotoxic effects of haloperidol and carbamazepine on the heart Haloperidol and carbamazepine are useful in the treatment of psychiatric disorders such as schizophrenia. Since carbamazepine inhibits the cytochrome P450s involved in the metabolism of haloperidol and tricyclic antidepressants (TCA), the combination of carbamazepine and TCA causes heart disease (such as delayed conduction and arrhythmia) P450 ...