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心元胶囊由首乌、丹参、三七、西洋参等中药组成,临床对治疗和预防冠心病等心血管疾病有肯定疗效。动物试验证明,小鼠灌胃急性毒性试验LD_(50)。为每公斤体重262.95(251.7～274.7)克原生药(相当于临床用药的1143倍。三个剂量组大白鼠90天灌胃长期毒性试验,最高剂量64.3g/kg原生药灌胃给药以及恢复期观察,对动物的行为活动,体重,血象,血生化,脏器指数无影响,主要脏器无组织形态改变。药效学证明15g/kg原生药具有明显的改善结扎麻醉杂种狗冠状动脉心肌缺血后的血流
Xinyuan capsules are composed of Shouwu, Salvia miltiorrhiza, Panax notoginseng, American ginseng and other traditional Chinese medicines, and have clinical efficacy in the treatment and prevention of cardiovascular diseases such as coronary heart disease. Animal experiments proved that the mice were gavage acute toxicity test LD_ (50). 262.95 (251.7 to 274.7) grams of proto-drug per kilogram of body weight (equivalent to 1143 times of clinical drug use. Three-dose group of rats administered 90-day long-term toxicity test, the highest dose of 64.3g/kg of the original drug was administered orally and recovered. At the time of observation, there was no effect on the animal’s behavioral activities, body weight, blood count, blood biochemistry, and organ index, and no changes were observed in the main organs.The pharmacodynamics demonstrated that 15g/kg of the original drug had significant improvement in the ligation of the anesthetized crossbred coronary myocardium. Post-ischemic blood flow