AIM:To observe the relationship between intestinal lumencolonization with Candida albicans and mucosal secretoryIgA(sIgA).METHODS:A total of 82 specific-pathogen-free mice weredivided randomly into control and colonization groups.AfterCandida albicans were inoculated into specific-pathogen-free mice,the number of Candida albicans adhering tocecum and mucosal membrane was counted.Thelymphocyte proliferation in Peyer’s patch and in laminapropria was shown by BrdU incorporation,while mucosalsIgA(surface membrane)isotype switch in Peyer’s patchwas investigated.IgA plasma cells in lamina propria wereobserved by immunohistochemical staining.Specific IgAantibodies to Candida albicans were measured with ELISA.RESULTS:From d 3 to d 14 after Candida albicans gavagingto mice,the number of Candida albicans colonizing in lumenand adhering to mucosal membrane was sharply reduced.Candida albicans translocation to mesenteric lymph nodesoccurred at early time points following gavage administrationand disappeared at later time points.Meanwhile,the contentof specific IgA was increased obviously.Proliferation anddifferentiation of lymphocytes in lamina propria were alsoincreased.CONCLUSION:Lymphocytes in lamina propria play animportant role in intestinal mucosal immunity of specific-pathogen-free mice when they are first inoculated withCandida albicans.The decreasing number of Candidaalbicans in intestine is related to the increased level ofspecific IgA antibodies in the intestinal mucus. AIM: To observe the relationship between intestinal lumencolonization with Candida albicans and mucosal secretory IgA (sIgA). METHODS: A total of 82 specific-pathogen-free mice were divided randomly into control and colonization groups. AfterCandida albicans were inoculated into specific-pathogen-free mice , the number of Candida albicans adhering tocecum and mucosal membrane was counted. The lymphocyte proliferation in Peyer’s patch and in laminapropria was shown by BrdU incorporation, while mucosals IgA (surface membrane) isotype switch in Peyer’s patch was investigated. IgA plasma cells in lamina propria wereobserved by immunohistochemical staining. Specific IgA antibodies to Candida albicans were measured with ELISA .RESULTS: From d 3 to d 14 after Candida albicans gavagingto mice, the number of Candida albicans colonizing in lumen and adhering to mucosal membrane was sharply reduced. Candida albicans translocation to mesenteric lymph nodesoccurred at early time points following gavage administrationand d isappeared at later time points. Meanwhile, the content of specific IgA was significantly changed. The role of the specific IgA was apparently increased. inoculated withCandida albicans.The decreasing number of Candida albicans in intestine is related to the increased level of specific IgA antibodies in the intestinal mucus.