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地高辛由于其化疗系数较小,为保证用药安全有效,临床常需对其进行血药浓度的监测,进行药物动力学和生物利用度的研究。鉴于采用唾液浓度比血清浓度更为简便优越,本文在研究健康人单次给药后血清和唾液浓度关系的基础上,比较了用两种浓度计算药物动力学参数和生物利用度的结果,为在临床研究实践中采用唾液浓度测定提供了依据。单次口服给予7名健康受试者以地高辛酒精溶液(8.3μg/kg),在给药后24小时内6个时间点分别以放射免疫分析法测定血清和唾液中地高辛的浓度,结果表明两者显著相关。在各相应时间两种浓度全部结果的相关性r=0.879(P<0.001),各相应时间两种浓度平均值的相关性r=0.999(P<0.001)。由上述血清和唾液药物浓度测得地高辛的主要药物动力学参数[α、t_(1/2)(α)、β和t_(1/2)(β)]和对3名受试者测定地高辛片
Because of its smaller chemotherapy coefficient, digoxin is often needed to monitor its plasma concentration in order to ensure its safety and efficacy. Pharmacokinetics and bioavailability are also studied. In view of saliva concentration is more simple and superior than serum concentration superior to this study in healthy people after single administration of serum and saliva concentration based on the comparison of two concentrations calculated pharmacokinetic parameters and bioavailability results for the In the clinical research practice using saliva concentration provides the basis. Seven healthy volunteers were orally administered with digoxin alcohol solution (8.3 μg / kg), and the concentration of digoxin in serum and saliva was determined by radioimmunoassay at 6 time points within 24 hours after administration , The results show that the two were significantly related. The correlation between the two results at all time points was r = 0.879 (P <0.001), with a correlation of r = 0.999 (p <0.001) for the mean of the two concentrations at each corresponding time. The predominant pharmacokinetic parameters of digoxin were determined from the above serum and salivary drug concentrations [α, t_ (1/2) (α), β and t_ (1/2) (β)] and on three subjects Determination of digoxin tablets