论文部分内容阅读
为观察加味四君子汤健脾化瘀治疗对N-甲基-N-硝基-亚硝基胍(MNNG)诱发大鼠胃癌的预防作用,探讨脾虚血瘀对胃癌发生发展的影响,将90只雄Wistar大鼠随机分成5组,每组18只,第1组为正常对照组;第2、3、4、5组用MNNG,第2组为单纯模型组,不加保护,第3组加用加味四君子汤,第4组用增液汤对照,第5组用生理盐水对照。喂养(28±2)周后观察各组大鼠的胃黏膜病变。83只大鼠完成实验。结果表明,MNNG组大鼠胃癌发生率37·5%(6/16),显著高于加味四君子汤干预组的5·9%(1/17),差异有显著意义(P<0·05),前者胃黏膜萎缩、肠上皮化生和异型增生发生率也显著高于后者(P<0·05)。增液汤组及生理盐水组大鼠胃癌发生率(33·3%,35·3%)与MNNG组比较无明显差异(P>0·05)。结论:脾虚血瘀可能是胃癌及癌前病变发生发展过程中的重要促进因素之一,加味四君子汤健脾化瘀治疗能有效地抑制MNNG诱发大鼠胃癌及癌前病变的发生。
To observe the preventive effect of Jiawei Sijunzi Decoction on the treatment of gastric cancer induced by N-methyl-N-nitro-nitrosoguanidine (MNNG) in rats, and to explore the effect of spleen deficiency and blood stasis on the occurrence and development of gastric cancer, 90 male Wistar rats The rats were randomly divided into 5 groups of 18 in each group. The first group was a normal control group; the second group was a MNNG group; the second group was a simple model group without protection; the third group was supplemented with a four-gentleman. In the soup, group 4 was fed with a soup control, and group 5 was treated with a saline control. After 28 (2 ± 2) weeks of feeding, gastric mucosal lesions were observed in each group of rats. Eighty-three rats completed the experiment. The results showed that the incidence of gastric cancer in MNNG rats was 37.5% (6/16), which was significantly higher than 5.9% (1/17) in the intervention group of Jiawei Sijunzi Decoction. The difference was significant (P<0.05). The rate of gastric mucosal atrophy, intestinal metaplasia and dysplasia was also significantly higher in the former (P < 0.05). The incidence of gastric cancer (33·3%, 35.3%) in Zengye decoction group and saline group was not significantly different from that in MNNG group (P>0.05). Conclusion: Spleen deficiency and blood stasis may be one of the important factors in the development of gastric cancer and precancerous lesions. Jiawei Sijunzi Decoction can effectively inhibit the occurrence of gastric cancer and precancerous lesions in rats induced by MNNG.