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本文报导用三-正丁基二硼酸酯的气液层析法测定药物制剂中山梨醇和甘露醇的含量。作者选用间-二苯基苯(每毫升含2.5毫克间-二苯基苯吡啶液)为内标,以克服由于使用其它一些己糖醇而引起的交叉污染问题。采用皖基硼酸有助于提高各种有机化合物的挥发度,并能溶解一般的已糖醇。本法的优点是制备衍生物容易,分析时间短.液相的热稳定性较大。对山梨醇、甘露醇样品进行了五次测试,所得的残留标准偏差为±1.2%。用气相层析仪附氢火焰离子化鉴知器。层析柱1.22米×0.64厘米(外径);固定相用2%OV-17涂
This article reports the determination of sorbitol and mannitol in pharmaceutical preparations by gas-liquid chromatography using tri-n-butyl diboronate. The authors selected m-diphenylbenzene (2.5 mg of m-DIPP per ml) as an internal standard to overcome cross-contamination problems caused by the use of some other hexitol. Wan Ji boric acid used to help improve the volatility of various organic compounds, and can dissolve the general hexitol. The advantage of this method is that the preparation of derivatives is easy and the analysis time is short. The thermal stability of the liquid phase is great. Five tests on sorbitol and mannitol samples resulted in a residual standard deviation of ± 1.2%. Gas chromatography with a flame ionization detector. Columns 1.22 m x 0.64 cm (outer diameter); stationary phase coated with 2% OV-17