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肺纤维化(FLD)的发病机制尚不清楚,近来的注意力集中于肥大细胞(MC)在纤维化发生的可能作用上.该项研究评价5组FLD 患者肺组织存在的MC与肺纤维化的可能关系.方法49例FLD 患者,均无个人和家族过敏性疾病史.其中16例结节病(A 组,平均年龄37.4±15.4岁),15例农民肺(B 组,45.8±8.2岁).9例隐原性致纤维化肺泡炎(C 组,52.1±16.4岁),6例阻塞性细支气管炎性机化性肺炎(D 组,61.6±7.4岁),3例组织细胞增多病X(E 组,36.6±21.3岁);均作支气管肺泡灌洗(BAL),并对其经支气管镜活检标本进行光镜检查.以7例肺癌患者(58.8±14.4岁)无病
The pathogenesis of pulmonary fibrosis (FLD) is unclear and recent attention has focused on the possible role of mast cells (MCs) in fibrosis.The study evaluated the presence of MC and pulmonary fibrosis in the lungs of five FLD patients .Among the 49 FLD patients, there was no history of individual and familial allergic diseases.Among them, 16 were sarcoidosis (group A, mean age 37.4 ± 15.4 years), 15 farmer’s lungs (group B, 45.8 ± 8.2 years ), 9 cases of cryptogenic alveolar fibrosis (C group, 52.1 ± 16.4 years), 6 cases of bronchiolitis obliterans (group D, 61.6 ± 7.4 years), 3 cases of histiocytosis X (E group, 36.6 ± 21.3 years old) were all treated with bronchoalveolar lavage (BAL) and bronchoscopic biopsy specimens were examined by light microscopy.Among 7 lung cancer patients (58.8 ± 14.4 years)