JAK/STAT通路是细胞因子、生长因子、激素等广泛应用的信号转导通路,白血病形成中普遍存在JAK/STAT通路的持续激活。白血病融合蛋白的表达、酪氨酸激酶过度表达或激活突变及某些病毒感染可导致JAK/STAT通路的持续激活和调节异常,并引起细胞的转化和白血病形成。了解白血病形成中JAK/STAT通路的异常调节有助于开发靶向JAK/STAT通路的治疗策略。 JAK / STAT pathway is a widely used signal transduction pathway such as cytokines, growth factors and hormones, and the continuous activation of JAK / STAT pathway is common in the formation of leukemia. Leukemia fusion protein expression, tyrosine kinase overexpression or activation mutations and certain viral infections can lead to sustained activation and modulation of the JAK / STAT pathway, and lead to cell transformation and leukemia formation. Understanding the aberrant regulation of the JAK / STAT pathway in leukemia contributes to the development of therapeutic strategies that target the JAK / STAT pathway.