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目的:讨论睾酮对精子活动的影响。方法:41例弱精子症患者口服十一酸睾酮(商品名:安特尔)治疗。患者平均年龄(33±6)岁,不育时间平均(4±3)年。结果:41例中,9例女方受孕,6例失访,3例未遵医嘱用药。26例用药超过3个月。26例治疗前精液体积为(2.90±0.60)ml,精子密度为(70.31±68.13),a级(9.54±4.74)%,b级(17.42±8.99)%,a级+b级(26.96±12.22)%。治疗后1、2、3个月,精液体积、密度、a级、b级、a级+b级精子百分比分别为(2.91±0.49、3.00±0.56、2.77±0.45)ml、(47.04±29.81、40.73±25.38、34.15±20.23)×10~6、(17.27±7.23、22.96±8.48、27.04±10.62)%、(28.00±9.05、32.77±9.97、34.96±12.45)%、(45.27±13.36、55.73±11.16、62.00±10.95)%。采用ANOVA、LSD检验分析组间差异,结果显示在0.05水平,精子密度、活动度治疗前后不同时间的差异均有统计学意义(P<0.05)。随着用药时间的推移,药物对精子密度、活动度的影响逐渐降低。用药后第1个月,精子活动度变化最明显,用药后第2个月与第3个月相比,精子活动度差异无统计学意义(P>0.05)。结论:十一酸睾酮可以引起精子密度下降,精子活动度增加,值得临床采用。
Objective: To discuss the effect of testosterone on sperm motility. Methods: 41 patients with asthenospermia were treated with testosterone undecanoate (trade name: Antel). The average age of patients (33 ± 6) years, the average time of infertility (4 ± 3) years. Results: Among the 41 cases, 9 women conceived, 6 were lost to follow-up, and 3 were not prescribed medication. 26 cases medication for more than 3 months. The sperm density was (70.31 ± 68.13), a grade (9.54 ± 4.74)%, b grade (17.42 ± 8.99)%, a grade + b grade (26.96 ± 12.22 )%. The percentage of semen volume, density, a grade, b grade, a grade + b grade were (2.91 ± 0.49,3.00 ± 0.56,2.77 ± 0.45) ml and (47.04 ± 29.81, 40.73 ± 25.38,34.15 ± 20.23) × 10 ~ 6, (17.27 ± 7.23,22.96 ± 8.48,27.04 ± 10.62)%, (28.00 ± 9.05,32.77 ± 9.97,34.96 ± 12.45)%, (45.27 ± 13.36,55.73 ± 11.16, 62.00 ± 10.95)%. The ANOVA and LSD tests were used to analyze the differences between groups. The results showed that there were significant differences at 0.05 level, sperm density and activity before and after treatment at different time points (P <0.05). With the passage of medication time, the impact of drugs on sperm density, activity decreased. There was no significant difference in sperm motility between the first month after treatment and the third month after administration (P> 0.05). Conclusion: Testosterone undecanoate can cause the sperm density to decrease and the sperm motility to increase, which deserves clinical application.