随着机械通气的开展,患有呼吸系统疾患如呼吸窘迫综合征(RDS)的早产儿存活率明显提高,随之与机械通气相关的慢性肺疾患(CLD)亦逐年增多,这严重影响早产儿的存活率和远期生活质量。允许性高碳酸血症(PHC)作为肺保护性机械通气策略在成人已有较多报道,其作用已肯定,然而在新生儿 With the development of mechanical ventilation, the survival rate of premature infants with respiratory diseases such as respiratory distress syndrome (RDS) is significantly increased, and subsequently the chronic lung disease (CLD) associated with mechanical ventilation is also increased year by year, which seriously affects premature infants Survival and long-term quality of life. Permissive hypercapnia (PHC) has been reported in adults as a protective pulmonary ventilation strategy, and its role is confirmed. However, in neonates