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肝细胞癌的发生与乙型肝炎（HB）和丙型肝炎（HC）之间的密切关系已被许多资料所确认。然而，日本一宗大型的流行病学研究发现17．7％的原发性肝癌其HB和HC的标志物为阴性．5．9％的肝癌则是源于正常的肝组织。在1991～1996年期间作者在收治的可切除肝癌病例中也发现了12例是没
The close relationship between the occurrence of hepatocellular carcinoma and hepatitis B (HB) and hepatitis C (HC) has been confirmed by many data. However, a large-scale epidemiological study in Japan found that 17.7% of primary liver cancer had negative HB and HC markers. 5.9% of liver cancer originated from normal liver tissue. During the period from 1991 to 1996, the author also found that 12 cases of resected liver cancer were not found.