In the present study,67 cases of hepatocellular carcinoma(HCC)were treated withimmunotherapy or immunochernotherapy.The results indicated that natural killer cell(NK)andantibody-dependent cytotoxicity cell(ADCC)activities and lymphocyte transformation rate(LTR)were significantly improved in vivo after treatment.The NK activity in tumor tissue,which showed aheavy immunosuppression,could also be enhanced and recovered to normal level after treatment withlymphokine mixture and 5-fluorouracil(5-FU).Immunity of host with postoperativeimmunochemotherapy was rapidly improved and recovery vate was high.The survival time in thesecases of unresectable tumors was obviously prolonged when a general immunotherapy was used.Immunochemotherapy can impr(?)ve immunity and inhibit selectively Ts cells as well as kill directly thetremor cells;therefore,it can play an important role in the treatment of hepatocellular carcinomaand in the prevention of its recurrence after operation. In the present study, 67 cases of hepatocellular carcinoma (HCC) were treated with immunotherapy or immunochernotherapy.The results indicated that natural killer cell (NK) and antibody-dependent cytotoxicity cell (ADCC) activities and lymphocyte transformation rate (LTR) were significantly improved in vivo after treatment. NK activity in tumor tissue, which showed aheavy immunosuppression, could also be enhanced and recovered to normal level after treatment with lymphatic mixture and 5-fluorouracil (5-FU). Immunity of host with postoperative immunochemotherapy was rapidly improved and recovery vate was high. survival time in thesecases of unresectable tumors was retard prolonged when a general immunotherapy was used. Immunochemotherapy can impr (?) ve immunity and inhibit selectively Ts cells as well as kill directly in the tremor cells; therefore, it can play an important role in the treatment of hepatocellular carcinoma and in the prevention of its recurrence after operation.