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目的:探讨中西医联合治疗高原地区慢性阻塞性肺疾病(COPD)对患者肺功能及炎症因子的影响。方法:选取2014年4月—2016年8月在本院住院治疗的高原地区稳定期COPD患者96例为研究对象,随机分为观察组与对照组,对照组患者给予常规西医治疗,观察组在对照组的基础上给以注射用益气复脉治疗,对比两组患者治疗前后肺功能相关指标[第一秒用力呼气容积(FEV1)/用力肺活量(FVC%)以及FEV1所占的预计值百分比(FEV1%)]、炎症因子相关指标[肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、白细胞介素-8(IL-8)]。结果:与治疗前对比,治疗后观察组与对照组患者的FEV1/FVC%、FEV1%均明显升高,且治疗后观察组患者的FEV1/FVC%、FEV1%较对照组升高更显著(P<0.05);与治疗前对比,治疗后观察组与对照组患者的TNF-α、IL-6及IL-8的水平均明显降低,且治疗后观察组患者的TNF-α、IL-6及IL-8的水平较对照组改善更显著,差异有统计学意义(P<0.05)。结论:常规西医联合益气复脉治疗高原地区稳定期COPD患者可有效改善患者肺功能及炎症因子水平。
Objective: To investigate the effect of traditional Chinese and western medicine on pulmonary function and inflammatory factors in patients with chronic obstructive pulmonary disease (COPD) in high altitude area. Methods: From April 2014 to August 2016 in our hospital 96 cases of stable COPD patients hospitalized for the study were randomly divided into observation group and control group, the control group of patients given conventional Western medicine, the observation group in the On the basis of the control group, the patients were given Yiqi Fumai injection. The FEV1 / FVC% and FEV1 percentage of predicted value before and after treatment were compared between the two groups (FEV1%)] and inflammatory cytokines (TNF-α, IL-6, IL-8). Results: Compared with those before treatment, FEV1 / FVC% and FEV1% of observation group and control group were significantly increased after treatment, and FEV1 / FVC% and FEV1% of observation group were significantly higher than those of control group after treatment P <0.05). Compared with those before treatment, the levels of TNF-α, IL-6 and IL-8 in the observation group and the control group were significantly decreased after treatment, and the levels of TNF-α, IL- And IL-8 levels improved more significantly than the control group, the difference was statistically significant (P <0.05). Conclusion: Conventional Western medicine combined with Yiqi Fumai in patients with stable COPD at high altitude can effectively improve pulmonary function and inflammatory cytokines levels.