近年来很多药剂工作者对在压片时所用压力下,颗粒的大小对压成片剂的溶解速率、崩解度、易碎性、硬度、压重差异等的影响以及测定颗粒强度的方法作了广泛的研究。本文报导压力与颗粒大小两者的连合对乳糖片物理标准的影响。颗粒的制备:将乳糖粉1000克与小麦淀粉50克混和,加进海藻酸钠溶液(20克溶于200毫升蒸馏水),置于捏和机中捏和15分钟。将此软材压过8号筛(英国药典)制成颗粒后于热空气干燥箱中干燥过夜。不加粘合剂也不加崩解剂的、只加粘合剂与只加崩解剂的对照颗粒的制备与上相同。颗粒的分级:用各级筛孔的筛子在振动器上振动30分钟,将颗粒分成平均大小为 In recent years, many pharmaceutical workers on the pressure at the time of compression, the size of the particles into the tablet dissolution rate, disintegration, friability, hardness, pressure difference between the impact of the method and the determination of particle strength Extensive research. This article reports the effect of the combination of pressure and particle size on the physical standard of lactose tablets. Preparation of granules: Combine 1000 grams of powdered lactose with 50 grams of wheat starch, add a sodium alginate solution (20 grams dissolved in 200 milliliters of distilled water) and place in a kneader for 15 minutes. The soft material was pressed through a No. 8 sieve (British Pharmacopoeia) into pellets and dried in a hot air oven overnight. The preparation of control granules with and without a disintegrant without binder and disintegrant was the same as above. Grading of particles: sieve sieve with various levels of vibration in the vibrator 30 minutes, the particles are divided into an average size of