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肝纤维化是慢性肝损伤后的修复反应过程,肝硬化是肝纤维化的最终发展阶段。目前研究表明,肝纤维化发生的中心环节是肝星状细胞(HSCs)的增生和激活。激活后的HSCs产生大量以胶原为主的细胞外基质(ECM)成分和细胞因子(CK)。本综
Liver fibrosis is a repair reaction after chronic liver injury, and cirrhosis is the final stage of development of liver fibrosis. The current study shows that the central part of liver fibrosis is the proliferation and activation of hepatic stellate cells (HSCs). Activated HSCs produce large amounts of extracellular matrix (ECM) components and cytokines (CK) that are predominantly collagen. This comprehensive