角蛋白是一组几乎存在于所有上皮细胞中的中丝蛋白。近年来,由于免疫学和生物化学技术的发展和广泛应用,对角蛋白的研究逐渐深入。除多克隆抗体外,用杂交瘤技术生产了多种特异性抗角蛋白单克隆抗体,应用于多种皮肤病的病因、发病机理探讨和诊断研究,取得了很多进展。本文将近年来有 Keratin is a group of mesoderm proteins that exist in almost all epithelial cells. In recent years, due to the development of immunology and biochemistry technology and its wide application, the research on keratin gradually goes deep. In addition to polyclonal antibodies, a variety of specific anti-keratin monoclonal antibodies have been produced using hybridoma technology and have been used in the study of the etiology, pathogenesis and diagnosis of various skin diseases. Much progress has been made. This article will be available in recent years