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本文采用白蛋白纳米反应器合成了Gd_2O_3/CuS双组分复合纳米粒,并将其成功应用于肿瘤的诊断与治疗.研究发现复合纳米粒中Gd/Cu比例可有效调控其纵向弛豫系数,其磁共振造影性能数倍于Gd-DTPA.同时,可通过化学偶联在蛋白表面修饰近红外荧光探针Cy7.5,得到Cy7.5-Gd_2O_3/CuS纳米粒,实现近红外荧光成像与磁共振成像的多模态成像.该复合纳米粒具有良好的光稳定性、较高的光热转换系数、较强的细胞摄取和肿瘤靶向效应,实现了精确的肿瘤光热消融治疗.该方法提供了一种快速、简便、通用的多组分纳米粒构建平台,为肿瘤诊疗一体化纳米材料的发展提供了新的契机.
In this paper, Gd_2O_3 / CuS bi-component composite nanoparticles were synthesized using albumin nanoreactor and successfully applied in the diagnosis and treatment of tumors.It was found that the Gd / Cu ratio in the composite nanoparticles could effectively control the longitudinal relaxation coefficient, Its magnetic resonance imaging performance is several times that of Gd-DTPA.Meanwhile, Cy7.5-Gd_2O_3 / CuS nanoparticle can be obtained by chemical coupling of near-infrared fluorescent probe Cy7.5 on the surface of protein to achieve near infrared fluorescence imaging and magnetic Resonance imaging of multimodal imaging.The composite nanoparticles have good light stability, high photothermal conversion coefficient, strong cell uptake and tumor targeting effect, to achieve accurate tumor photothermal ablation therapy. The method Provides a fast, simple and versatile multi-component nanoparticle construction platform, which provides a new opportunity for the development of integrated nanomaterials for tumor diagnosis and treatment.