慢性肉芽肿(CGD)是一种表现为吞噬细胞功能异常的遗传性疾病。病人的嗜中性、嗜酸性、单核及巨噬细胞的吞噬功能均正常,但不能杀死触酶阳性的细菌和真菌。其机理是不能把分子氧转化成过氧化氢及O_2~-、OH~-、OCl~-等杀菌基团。细菌被吞噬后反而受到保护,不易被大多数抗菌素和血清物质杀伤,以致进入每一器官,引起复发性和播散性感染。从这种感染部位分离到的微生物包括葡萄球 Chronic granulomatous (CGD) is a hereditary disease manifested as dysfunction of phagocytes. The patient’s neutrophilic, eosinophilic, monocyte and macrophage phagocytosis are normal, but can not kill the enzyme-positive bacteria and fungi. The mechanism is that the molecular oxygen can not be converted into hydrogen peroxide and bactericidal groups such as O 2 -, OH ~ - and OCl ~ -. Instead, the bacteria are swallowed, protected from most antibiotics and serums, and enter each organ causing recurrent and disseminated infections. Microorganisms isolated from this site of infection include the grape ball