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树突状细胞(dendritic cells,DCs)是体内已知的功能最强大的专职抗原提呈细胞,对于诱导机体初始免疫应答尤为重要。趋化受体因子7(chemokine receptor 7,CCR7)是一个已知的调节各类免疫细胞向初级、次级淋巴细胞分化,并向外周淋巴器官归巢的趋化因子受体,其具有自我平衡表达能力,在趋化DCs从外周组织迁移至次级淋巴器官中起关键作用。随着研究的深入,除了CCR7最主要的趋化作用外,更多的功能逐渐被了解。目前,DCs和CCR7的相关功能已被应用于诱导角膜移植后的免疫耐受等眼科领域。就CCR7在DCs中的功能及其对角膜免疫调节的影响进行综述,探讨其关键作用及可能的治疗靶点。
Dendritic cells (DCs) are the most potent professional antigen-presenting cells known in the body and are particularly important for inducing the initial immune response. Chemokine receptor 7 (CCR7) is a known chemokine receptor that regulates the differentiation of various types of immune cells into primary and secondary lymphocytes and homing to peripheral lymphoid organs. It has a homeostasis Expression plays a key role in the migration of chemotactic DCs from peripheral tissues to secondary lymphoid organs. With the deepening of research, in addition to the main chemotactic effect of CCR7, more and more functions are gradually understood. At present, the related functions of DCs and CCR7 have been applied to ophthalmology fields such as immunotolerance after corneal transplantation. The function of CCR7 in DCs and its impact on corneal immunoregulation were reviewed to explore its key role and possible therapeutic targets.