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自心得安应用于临床16年来,具有不同药物代谢动力学(简称药代动力学)与药效动力学的β阻滞剂相继问世,已有30余种用于临床,对其中10余种积累了大量经验。在各种心血管病中,高血压是其应用最活跃的领域,因疗效好,使用安全,副作用少而成为许多轻、中度高血压病的首选药物。临床药理学已知细胞膜上存在几种腺甙酸环化酶的受体(包括对β兴奋剂、高血糖素、甲状腺素及组织胺的受体),作用于这些受体均可活化腺甙酸环化酶,促进环磷酸腺甙的合成,环磷酸腺
Self-reliance applied to clinical 16 years, with different pharmacokinetics (pharmacokinetics) and pharmacodynamics of β-blockers have come out, there are more than 30 kinds of clinical use, of which more than 10 kinds of accumulation A lot of experience. In a variety of cardiovascular diseases, hypertension is the most active areas of its application, because of good efficacy, safe use, fewer side effects and become the first choice for many mild to moderate hypertension. Clinical Pharmacology There are several receptors for adenosine cyclase (including receptors for beta-agonists, glucagon, thyroid hormone, and histamine) found on the cell membrane and act on these receptors to activate adenosine Acid cyclase, promote the synthesis of cyclic adenosine monophosphate, cyclophosphate gland