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最近,作者应用茶硷制剂治疗哮喘患儿过程中,发现已控制的癫痫复发,从而对患有癫痫与支气管哮喘两种疾病患儿的长期治疗问题进行了探讨。 茶硷的有效血药浓度范围很窄,为10～20μg/ml。5μg/ml以下无效:5～10μg/ml部分患者有效:10～20μg/ml多数患者有效:20～25μg/ml部分患者有效,可引起消化系症状及心率加快(100～119次/分)等中毒反应:25～40μg/ml可引起多数患者中毒,表现为心动过速(120次/分以上),呼吸困难及心律失常、痉挛:40～60μg/ml全部患者中毒,出现中枢神系统症状,心律失常、痉挛:60μg/ml以上出现痉挛甚至死亡。药物剂量与血药浓度的关系随代谢功能
Recently, the authors used the theophylline preparation to treat children with asthma and found that the controlled epilepsy was recurring, so as to discuss the long-term treatment of children with both epilepsy and bronchial asthma. Theophylline effective blood concentration range is very narrow, 10 ~ 20μg / ml. 5μg / ml the following invalid: 5 ~ 10μg / ml effective in some patients: 10 ~ 20μg / ml effective in most patients: 20 ~ 25μg / ml effective in some patients can cause digestive symptoms and heart rate (100 ~ 119 beats / min) Toxicity: 25 ~ 40μg / ml can cause poisoning in most patients, manifested as tachycardia (120 beats / min), dyspnea and arrhythmia, spasm: 40 ~ 60μg / ml all patients poisoning, central nervous system symptoms, Arrhythmia, spasm: Spasms or even death above 60 μg / ml. The relationship between drug dose and plasma concentration with metabolic function