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目的通过测定重型肝炎患者外周血中CD3+、CD3+CD4+及CD3+CD8+T淋巴细胞数量的变化,探讨重型肝炎T淋巴细胞亚群数量的变化与临床转归的相关性。方法使用流式细胞仪对36例重型肝炎早、晚期外周血中CD3+、CD3+CD4+及CD3+CD8+T淋巴细胞数量进行检测。结果 36例重型肝炎早期外周血中CD3+、CD3+CD4+及CD3+CD8+T淋巴细胞数量分别为:(1274.62±273.79)个/μl、(554.27±152.95)个/μl、(541.77±184.77)个/μl,晚期分别为:(874.14±312.89)个/μl、(467.77±144.57)个/μl、(326.86±124.01)个/μl(P分别<0.05、<0.01),有统计学意义;死亡患者早期CD3+、CD3+CD4+及CD3+CD8+T淋巴细胞数量分别为:(1329.50±276.58)个/μl、(731.00±212.81)个/μl、(571.75±231.24)个/μl,晚期分别为:(662.75±187.46)个/μl、(376.50±120.09)个/μl、(205.25±186.03)个/μl(P分别<0.05、<0.01),有统计学意义;成活与死亡患者晚期外周血中CD3+、CD3+CD4+及CD3+CD8+T淋巴细胞数量比较,P<0.01,有统计学意义。结论重型肝炎早期外周血中CD3+、CD3+CD4+及CD3+CD8+T淋巴细胞数量明显高于晚期;成活患者晚期外周血中CD3+、CD3+CD4+及CD3+CD8+T淋巴细胞数量明显高于死亡患者;免疫调节剂的使用,可提高重型肝炎抢救的成功率。
Objective To investigate the changes of the number of T lymphocyte subsets in patients with severe hepatitis and the clinical outcome by measuring the changes of the numbers of CD3 +, CD3 +, CD4 + and CD3 + CD8 + T lymphocytes in peripheral blood of patients with severe hepatitis. Methods The numbers of CD3 +, CD3 +, CD4 + and CD3 + CD8 + T lymphocytes in peripheral blood of 36 patients with severe hepatitis were detected by flow cytometry. Results The numbers of CD3 +, CD3 +, CD4 + and CD3 + CD8 + T lymphocytes in peripheral blood of 36 patients with severe hepatitis were (1274.62 ± 273.79) / μl, (554.27 ± 152.95) / μl, (541.77 ± 184.77) / μl, and advanced stage were (874.14 ± 312.89) / μl, (467.77 ± 144.57) / μl, (326.86 ± 124.01) / μl respectively (P <0.05, <0.01, respectively; The numbers of early CD3 +, CD3 +, CD4 + and CD3 + CD8 + T lymphocytes were (1329.50 ± 276.58) / μl, (731.00 ± 212.81) / μl, and (571.72 ± 231.24) / μl, respectively, 662.5 ± 187.46) / μl, (376.550 ± 120.09) / μl, (205.25 ± 186.06) / μl (P <0.05, <0.01 respectively), with significant difference between the surviving and the dead patients’ peripheral blood CD3 + The number of CD3 + CD4 + and CD3 + CD8 + T lymphocytes were compared, P <0.01, with statistical significance. Conclusion The numbers of CD3 +, CD3 +, CD4 + and CD3 + CD8 + T lymphocytes in peripheral blood of patients with severe hepatitis were significantly higher than those in the late stage. The numbers of CD3 +, CD3 +, CD4 + and CD3 + CD8 + Patients; The use of immunomodulatory agents can improve the success rate of severe hepatitis rescue.