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目的进行小剂量红霉素预防早产儿喂养不耐受的临床观察。方法符合入选条件的早产儿68例,随机分为预防治疗组(用药组)35例和对照组33例。治疗组采用静脉滴注10mg/(kg.min)的小剂量红霉素,连用7天。其他治疗措施两组相同。结果用药组28.57%(10/35)出现喂养不耐受,低于对照组的54.54%(18/33),差异有统计学意义(χ2=3.89,P<0.05)。用药组达到完全经肠道喂养的时间、黄疸持续时间、住院时间、每天大便次数均有明显差异,33例对照组有5例出现胆汁淤积性黄疸,而用药组有2例出现,但差别无统计学意义(χ2=1.89,P>0.05)。两组中各有2例发生NEC,均无心律失常的发生;用药组无一例出现肝功能损害。结论小剂量红霉素预防早产儿喂养不耐受是安全有效的。
Objective To observe the clinical efficacy of low dose erythromycin in preventing intolerance in preterm infants. Methods A total of 68 preterm infants were enrolled in the study. They were randomly divided into prevention and treatment group (35 cases) and control group (33 cases). The treatment group with intravenous infusion of 10mg / (kg.min) of small doses of erythromycin, once every 7 days. Other treatments are the same for both groups. Results In 28.57% (10/35) of drug-treated groups, feeding intolerance occurred, which was lower than that of control group (54.54%, 18/33). The difference was statistically significant (χ2 = 3.89, P <0.05). The time to complete enteral feeding, the duration of jaundice, length of hospital stay, and the number of stools in each group were all significantly different from those in the control group. Cholestatic jaundice was found in 5 of the 33 patients in the control group and 2 in the drug-treated group, but the difference was no Statistical significance (χ2 = 1.89, P> 0.05). NEC occurred in 2 of 2 cases in each group, and no arrhythmia occurred. No liver damage occurred in the medication group. Conclusions It is safe and effective to prevent low dose erythromycin from feeding intolerance in preterm infants.