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为了比较不同的促排卵方法联合宫腔内人工授精（ＩＵＩ）治疗不育症的疗效。以排卵功能障碍、宫颈因素、免疫因素、原因不明、男方因素等导致不育的１４７对不育夫妇作为观察对象，分为３组。第一组：促性腺激素促排卵加ＩＵＩ，共５６例、６８周期；第二组：克罗米芬促排卵联合ＩＵＩ，共５０例，５６周期；第三组：自然周期加ＩＵＩ共４１例、４１周期。结果：第一组１６例妊娠，妊娠率２９％，周期妊娠率２４％；第二组３例妊娠，妊娠率６％，周期妊娠率５％；第三组妊娠３例，妊娠率与周期妊娠率均为７％。第一组与第二、第三组的妊娠率及周期妊娠率比较，差异均有显著意义，分别为Ｐ＜０．０１及Ｐ＜０．０２。结论：对难治性不育症，如选用ＩＵＩ治疗，则加用促性腺激素促排卵的妊娠率高于克罗米芬刺激排卵或不刺激周期。
In order to compare different ovulation induction methods combined with intrauterine insemination (IUI) treatment of infertility. 147 pairs of infertile couples with ovulation dysfunction, cervical factors, immune factors, unexplained causes, male factors and so on were taken as observation objects and divided into 3 groups. The first group: ovulation induction plus IUI gonadotropin, a total of 56 cases, 68 cycles; the second group: clomiphene combined ovulation induction IUI, a total of 50 cases, 56 cycles; the third group: natural cycle plus IUI total 41 cases, 41 cycle. Results: The first group of 16 pregnancies, the pregnancy rate was 29%, the cycle pregnancy rate was 24%; the second group of 3 cases of pregnancy, the pregnancy rate was 6%, the cycle pregnancy rate was 5%; the third group of pregnancy in 3 cases, pregnancy rate and cycle pregnancy The rate is 7%. The difference of pregnancy rate and cycle pregnancy rate among the first group, the second group and the third group was significant (P <0.01 and P <0.02, respectively). Conclusion: For refractory infertility, if IUI treatment is used, the pregnancy rate of ovulation plus gonadotropin is higher than that of clomiphene to stimulate ovulation or non-stimulation period.