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FHIT基因跨越脆性部位FRA3B和(t3;8)易位断裂处,定位于染色体3P14.2的一个抑癌候选基因。人类多种肿瘤组织或肿瘤来源的细胞系中出现3号染色体短臂高频率杂合性缺失(lossofheterozygosity,LOH)。但其与泌尿系肿瘤的关系尚不清楚。就该基因与泌尿系肿瘤的关系的研究进展进行综述。
The FHIT gene crosses the FRA3B and (t3; 8) translocations at the fragile site and is located on chromosome 3P14.2 as a tumor suppressor candidate gene. In human multiple tumor tissues or tumor-derived cell lines, short arm high frequency loss of heterozygosity (LOH) on chromosome 3 occurs. But its relationship with urological tumors is not clear. This article reviews the relationship between this gene and urological tumors.