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目的探讨产后出血高危因素孕妇在剖宫产术中预防性宫体注射卡前列素氨丁三醇减少产后出血的临床疗效。方法 132例行剖宫产手术具有产后出血高危因素孕妇,根据治疗方式不同分为对照组(56例)和研究组(76例)。所有孕妇均采取新型子宫下段剖宫产术分娩,对照组孕妇在娩出胎儿后给予常规药物预防产后出血,研究组孕妇予以缩宫素联合卡前列素氨丁三醇子宫注射预防产后出血。比较两组临床效果。结果研究组产后出血率、贫血率、子宫切除率均明显低于对照组(P<0.05);研究组手术后2、4 h出血量,及第三产程时间、止血时间明显优于对照组(P<0.05);研究组不良反应发生率为1.3%,对照组为12.5%,研究组不良反应发生率明显低于对照组(P<0.05)。结论对产后具有高危因素的孕妇在行剖宫产手术时预防性注射卡前列素氨丁三醇有助于降低产后出血的发生,且不良反应轻微,值得临床推广应用。
Objective To investigate the clinical efficacy of prophylactic uterine injection of carboprost in the cesarean section to reduce postpartum hemorrhage in pregnant women at risk of postpartum hemorrhage. Methods 132 pregnant women with high risk factors for postpartum hemorrhage undergoing cesarean section were divided into control group (56 cases) and study group (76 cases) according to different treatment methods. All pregnant women took a new cesarean delivery of the lower uterine segment. Pregnant women in the control group were given routine drugs to prevent postpartum hemorrhage. The pregnant women in the study group were given oxytocin combined with carboprost trometamol intrauterine injection to prevent postpartum hemorrhage. The clinical effects of two groups were compared. Results The postpartum hemorrhage rate, anemia rate and hysterectomy rate in the study group were significantly lower than those in the control group (P <0.05). The bleeding volume, the third stage of labor and the bleeding time in the study group were significantly better than those in the control group P <0.05). The adverse reaction rate was 1.3% in the study group and 12.5% in the control group. The incidence of adverse reactions in the study group was significantly lower than that in the control group (P <0.05). Conclusion Prenatal risk factors for pregnant women in the cesarean section during the prophylactic injection of carboprost tromethamine can help reduce the incidence of postpartum hemorrhage, and minor adverse reactions, it is worth promoting the clinical application.