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近期,来自英国牛津大学的Wong博士等在EHJ上发表了一篇关于心外膜脂肪与心房颤动(房颤)的综述,本文为该综述的十点小结。1.体质指数(BMI)是房颤的强力预测因子,BMI每增加5 kg/m2,房颤风险增加10%~30%。2.肥胖与心外膜脂肪增加相关,而后者是肥胖与房颤相关的主要介导因素。3.心外膜脂肪增加房颤风险的可能机制之一是脂肪细胞直接渗透到心房心肌,导致传导减慢或不一致。4.心外膜脂肪增加房颤风险的可能机制之二是心外膜脂肪分泌脂肪因子,导致心房纤维化。5.心外膜脂肪增加房颤风险的可能机制之三是心外膜脂肪分泌白介素6(IL-6)、IL-8和肿瘤坏死
Recently, Dr. Wong from the University of Oxford published an overview of epicardial fat and atrial fibrillation (atrial fibrillation) at EHJ, a ten-point summary of the review. Body mass index (BMI) is a strong predictor of atrial fibrillation, BMI increased by 5 kg / m2, the risk of atrial fibrillation increased by 10% to 30%. 2. Obesity is associated with increased epicardial fat, which is the major mediator of obesity associated with atrial fibrillation. 3. One of the possible mechanisms by which epicardial fat increases the risk of atrial fibrillation is the direct infiltration of adipocytes into the atrial myocardium, resulting in slow or inconsistent conduction. Epicardial fat increases the risk of atrial fibrillation is the second possible mechanism of epicardial adipose fat secretion, leading to atrial fibrosis. 5. The third possible mechanism by which epicardial fat increases the risk of atrial fibrillation is epicardial fat secretion of interleukin 6 (IL-6), IL-8 and tumor necrosis